Science

Here's why nerve agents are some of the most deadly chemicals on Earth

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Chemical weapons like sarin and VX are known to kill men, women, and children with gruesome efficiency.

While their names differ, both are members of a larger group of human-made substances, called nerve agents, that all target the same system in the body.

The five most common and important nerve agents are tabun, sarin, soman, GF, and VX, according to the Organization for the Prohibition of Chemical Weapons. In pure form, each is a colorless and mostly odorless liquid.

Any nerve agent can affect a person through the skin, breathing, ingestion, or all three routes, depending on the substance and how it's used. For example, VX resembles a thick oil but dissolves in water (a drop was enough to kill Kim Jong Un's brother), while sarin (which was spread over a Syria's Idlib province on April 4) quickly evaporates into the air.

Special bombs can weaponize these liquids by rapidly dispersing them into a breathable form.

These two graphics illustrate what nerve agents do to the body and the biochemistry of how they work.

nerve agent chemical weapons symptoms effects sarin vx tabun soman gf business insider
Diana Yukari/Business Insider

The way nerve agents attack the body's cholinergic system produces these and other symptoms.

Specifically, the chemicals target an enzyme that drifts in the spaces, or synapses, between nerve cells and muscle cells.

how nerve agent chemical weapons work biochemistry sarin vx tabun soman gf business insider
Diana Yukari/Business Insider

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Dave Mosher reported news and features stories about science and technology for Insider, with human and robotic spaceflight as the primary focus of his multimedia storytelling. Mosher joined Insider in April 2015 as a deputy editor to help launch Tech Insider and manage its science desk. He left the company in February 2021. Prior to being an Insider, Mosher directed Popular Science's website, was a Wired contributor, and worked for or with Scientific American, Popular Mechanics, Discover, Space.com, National Geographic NewsDiscovery Channel, Nature, Science, and other media outlets.
Diana is the Business Insider Graphics Intern. She recently graduated from the School of the Art Institute of Chicago in Visual Communication Design. She's a feminist, a capricorn and a history buff.